Efficacy and safety of teneligliptin
نویسنده
چکیده
11 Incretin‐based therapies (IBT) including dipeptidyl peptidase‐4 inhibitors (DPP‐4Is) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have been the cornerstone of therapy for type 2 diabetes mellitus (T2DM) since the evolution of incretin science. DPP‐4Is are particularly popular in the treatment of T2DM as they are oral drugs, less costlier than GLP‐RAs, with modest to moderate glucose lowering similar to sulfonylureas (SU) depending on the baseline glycemic load. DPP‐4Is carries novel mechanism of action and also have additional potential to protect from hypoglycemia, through unique glucagon dynamics.[1] Indeed, consensus statements from the American College of Endocrinology/American Association of Clinical Endocrinologist and the Latin American Diabetes Association consider DPP‐4I ahead of SU, mainly driven by their lower risk of hypoglycemia as well as weight neutrality.[2,3]
منابع مشابه
Efficacy and safety of teneligliptin in combination with pioglitazone in Japanese patients with type 2 diabetes mellitus
AIM To confirm the efficacy and safety of teneligliptin in combination with pioglitazone in Japanese patients with type 2 diabetes mellitus inadequately controlled with pioglitazone monotherapy. MATERIALS AND METHODS In an initial 12-week, double-blind, placebo controlled, parallel-group study, patients (n = 204) were randomized to teneligliptin 20 mg or placebo once daily added to their stab...
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